Affordable Access

Publisher Website

Studies on the fate of quinoline yellow in the rat

Authors
Journal
Food and Cosmetics Toxicology
0015-6264
Publisher
Elsevier
Publication Date
Volume
17
Issue
1
Identifiers
DOI: 10.1016/0015-6264(79)90150-0
Disciplines
  • Biology

Abstract

Abstract The uptake, fate and excretion of quinoline yellow in the rat were studied. In the isolated perfused liver 70% of the dose was excreted into the bile within 3 hr. Similar results were obtained after intravenous injection into anaesthetized animals. When given by gavage, only about 1% was excreted in bile and urine within 4–5 hr. Quinoline yellow administered orally to rats was quantitatively excreted, the excretion being mainly faecal. Administration of quinoline yellow did not affect the activities of two microsomal enzymes, N-aminopyrine demethylase and aniline hydroxylase. It is concluded that very little quinoline yellow is absorbed from the gastro-intestinal tract of the rat. No evidence of metabolism was obtained.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Studies on the fate of quinoline yellow in the rat...

on Food and cosmetics toxicology February 1979

The influence of quinoline yellow on potassium alu...

on Journal of Crystal Growth Jan 01, 1976

Adsorption and desorption studies of a water solub...

on Journal of Colloid and Interfa... Jan 01, 2005
More articles like this..