Abstract Direct and indirect non-aqueous titrimetric methods for the determination of mebendazole are presented. These methods are reproducible, with relative standard deviations of 0.3%. Mebendazole in tablets (100 mg per tablet) has also been determined spectrophotometrically with use of perchloric acid as solvent. The relative standard deviation was 1.4%. The methods are easy to automate for routine analysis.