Affordable Access

Publisher Website

New estrogenic compounds isolated from Broussonetia kazinoki

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
20
Issue
12
Identifiers
DOI: 10.1016/j.bmcl.2010.04.064
Keywords
  • Estrogen Receptor
  • Phytoestrogen
  • Broussonetia Kazinoki

Abstract

Abstract Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Studies on the constituents of Broussonetia specie...

on CHEMICAL & PHARMACEUTICAL BULL... November 2001

Five new diprenylated flavonols from the leaves of...

on Journal of Natural Products September 2001

Studies on the constituents of Broussonetia specie...

on CHEMICAL & PHARMACEUTICAL BULL... June 1998

Studies on the constituents of Broussonetia specie...

on CHEMICAL & PHARMACEUTICAL BULL... April 2001
More articles like this..