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Two distinct succinate thiokinases in both bloodstream and procyclic forms ofTrypanosoma brucei

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
151
Issue
1
Identifiers
DOI: 10.1016/0006-291x(88)90587-6
Disciplines
  • Biology
  • Communication

Abstract

Abstract Two succinate thiokinase activities specific for either adenine or guanine nucleotides have been found in Trypanosoma brucei . Key glycolytic and citric acid cycle enzymes were measured to show repression of glycolysis and derepression of the citric acid cycle in the procyclic form, relative to the bloodstream form. A marked rise in adenine-linked succinate thiokinase activity accompanied a rise in activity of citric acid cycle enzymes. However, guanine-linked succinate thiokinase was found to increase only slightly in activity. These results implicate the adenine-linked enzyme as an essential component of the citric acid cycle, whereas the guanine-linked enzyme appears to be under separate control. This communication also reports for the first time the occurrence of citrate synthase activity in the bloodstream (long slender) form of T.brucei .

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