Background The term oral allergy syndrome (OAS) describes an IgE-mediated reaction that takes place minutes after ingestion of some food to which the organism is previously sensitized. The clinical manifestations are typically localized to the mouth and throat. Oral allergy syndrome is commonly elicited by fresh fruits and vegetables, especially in subjects with hypersensitivity to pollens. Methods We report a patient witht OAS following intake of chicken meat. We performed (1) skin prick test to chicken meat, egg, milk, and wheat and to common inhalants, (2) determination of serum specific IgE, (3) histamine release test, and (4) in vitro antigen-specific production of sulphidoleukotrienes and challenge test with chicken meat. Results Skin prick test was positive only for chicken meat. The patient had serum specific IgE, postiive histamine release test, and specific production of sulphidoleukotrienes to chicken meat. We confirmed these findings by means of the challenge test.