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HFC-134a as a fluorinated building block: short syntheses of α-fluoroenones

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
41
Issue
6
Identifiers
DOI: 10.1016/s0040-4039(99)02184-x

Abstract

Abstract 1,1,1,2-Tetrafluoroethane (HFC-134a) has been transformed into a range of α-fluoroenones via a direct route. Dehydrofluorination/metallation allowed trifluorovinylsilanes to be prepared; these could be converted in situ, or isolated and treated further, with alkyllithium reagents to give difluorovinylsilanes. Fluoride-catalysed addition to aldehydes followed by acidic work-up allowed the isolation of a range of α-fluoroenones in two- or three-pots.

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