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Mechanism of reaction of peroxomethyl radicals with copper(II)(glycine)2and copper(II)(glycylglycylglycine) in aqueous solutions

Authors
Journal
Inorganica Chimica Acta
0020-1693
Publisher
Elsevier
Publication Date
Volume
358
Issue
7
Identifiers
DOI: 10.1016/j.ica.2005.02.004
Keywords
  • Copper Complexes
  • Peroxyl Radicals
  • Biological Ligands
Disciplines
  • Biology

Abstract

Abstract The reactions of O 2CH 3 radicals with Cu II(glycine) 2 and Cu II(GGG), GGG = glycylglycylglycine, in aqueous solutions were studied. The results demonstrate that the peroxyl radicals oxidize the copper complexes forming relatively stable intermediates of the type L mCu III-OOCH 3. These intermediates decompose via oxidation of the ligands glycine and GGG, respectively. Substituents on the alkyl of the peroxyl radical affect somewhat the kinetics of reaction but not the mechanism of oxidation. It is suggested that analogous reactions are probably contributing to the radical-induced deleterious biological processes.

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