Policosanol is an agent that includes mixtures of aliphatic primary alcohols extracted primarily from sugercane wax. Policosanol has been shown to lower total and LDL cholesterol in animal models, healthy volunteers and hypercholesterolemic patients. However, these findings have been challanged recently. Up to now, there has been no study investigating the effects of policosanol on blood coagulation factors.This study investigated the effects of rice policosanol (Oryza sp.) 10 mg/day on blood coagulation factors in 66 hypercholesterolemic patients of both sexes aged 20 to 78 years in a single center, randomized, double-blind, placebo-controlled, crossover trial. After an 8-week run-in period in which patients were placed on therapeutic lifestyle changes, in particular a cholesterol-lowering diet, they were randomly assigned to receive rice policosanol 10 mg tablets or placebo tablets once daily with the evening meal for 8 weeks. During next 8 weeks those receiving policosanol during the first 8 weeks, received placebo and those taking placebo during the first 8 weeks, received policosanol. Plasma fibrinogen, factors VII,VIII, XII and XIII were measured before and after the treatment. Rice policosanol treatment did not change significantly neither fibrinogen nor factors VII,VIII, XII and XIII.