Summary A case of varicella gangrenosa ina 3-year-old Negro boy is presented. The gangrene, involving the skin of both lower extremities and the left foot, required skin grafting of these areas and amputation of the toes of the left foot. No specific hematological cause for the development of gangrene was found. A discussion of theories regarding the etiology and pathogenesis of varicella gangrenosa is presented. It is difficult to place this child in any of these specific categories with the possible exception of individual susceptibility.