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Preventive potential of body mass reduction to lower cardiovascular risk: The Italian Progetto CUORE study

Authors
Journal
Preventive Medicine
0091-7435
Publisher
Elsevier
Publication Date
Volume
47
Issue
1
Identifiers
DOI: 10.1016/j.ypmed.2008.01.023
Keywords
  • Body Mass Index
  • Cardiovascular Disease
  • Coronary Heart Disease
  • Population Data
  • Prevention
  • Weight Reduction
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract Objective To estimate effects of weight change on incidence of major cardiovascular events in the Italian population-based Progetto CUORE. Methods Prospective observation in 12 Italian population-based cohorts on etiology of cardiovascular disease. Twenty-thousand six-hundred-forty-seven men and women aged 35–69 years without previous CVD, examined at baseline between 1984 and 1993 and followed for median time 8.5 years, with validated first cardiovascular events. Standardised anthropometric variables, lifestyle and biochemical risk factors for CVD; major cardiovascular events as end-points. Results Linear regression between BMI and major CVD risk factors was combined with Cox coefficients from a prediction model of CVD, CHD and stroke using major risk factors as dependent variables. Estimated cardiovascular risk reductions with BMI lowered by 1 to 3 U were: for men 3.8% to 10.9% for all cardiovascular events, 4.2% to 12.1% for CHD, and 2.3% to 6.9% for stroke; for women 2.8% to 8.1% for all cardiovascular events, 3.4% to 9.8% for CHD, and 2.1% to 6.2% for stroke. Conclusions Body weight level influences cardiovascular disease risk in the Italian population.

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