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Myasthenia gravis and pregnancy: clinical implications and neonatal outcome

Authors
Publisher
BioMed Central
Publication Date
Source
PMC
Keywords
  • Research Article
Disciplines
  • Medicine

Abstract

1471-2474-5-42.fm ral ss BioMed CentBMC Musculoskeletal Disorders Open AcceResearch article Myasthenia gravis and pregnancy: clinical implications and neonatal outcome José F Téllez-Zenteno*1, Lizbeth Hernández-Ronquillo†2, Vicente Salinas†3, Bruno Estanol†1 and Orlando da Silva†2 Address: 1Department of Neurology, National Institute of Medical Sciences and Nutrition. "Salvador Zubirán", Mexico City, Mexico, 2Department of Pediatrics, University of Western Ontario, London, Ontario, Canada and 3Neonatology Unit. National Institute of Perinatology, Mexico City, Mexico Email: José F Téllez-Zenteno* - [email protected]; Lizbeth Hernández-Ronquillo - [email protected]; Vicente Salinas - [email protected]; Bruno Estanol - [email protected]; Orlando da Silva - [email protected] * Corresponding author †Equal contributors Abstract Background: The myasthenia gravis is twice as common in women as in men and frequently affects young women in the second and third decades of life, overlapping with the childbearing years. Generally, during pregnancy in one third of patients the disease exacerbates, whereas in two thirds it remains clinically unchanged. Complete remission can occur in some patients. Methods: To describe the clinical course, delivery and neonatal outcome of 18 pregnant women with the diagnosis of myasthenia gravis. Retrospective chart review of pregnant patients with myasthenia gravis, followed at the National Institute of Perinatology in Mexico City over an 8-year period. Data was abstracted from the medical records on the clinical course during pregnancy, delivery and neonatal outcome. Results: From January 1, 1996 to December 31, 2003 18 patients with myasthenia gravis were identified and included in the study. The mean ± SD maternal age was 27.4 ± 4.0 years. During pregnancy 2 women (11%) had an improvement in the clinical symptoms of myasthenia gravis, 7 women (39%) had clinical worsening of the condition of 9 other patients (50%) remained c

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