Affordable Access

Beta7 integrins contribute to skin graft rejection.

Authors
Journal
Transplantation Journal
0041-1337
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date

Abstract

Because integrins alpha4beta7 and alphaEbeta7 contribute to epidermotropism of T-cells during skin inflammation, we sought to study their role in skin allograft rejection.Wild-type (WT) (beta7+/+) and beta7 gene knockout (beta7-/-) C57BL/6 (H-2(b)) mice and SJL/J (H-2(s)) mice served as donors and recipients of allogeneic skin grafts. An anti-integrin beta7 subunit mAb (FIB504.64) was used to treat WT beta7+/+ C57BL/6 recipients of skin grafts from SJL/J mice.WT C57BL/6 recipients acutely rejected skin from SJL/J mice in 13 days. In contrast, the survival of SJL/J skin on either beta7-/- gene knockout or WT C57BL/6 recipients treated with anti-beta7 subunit mAb, was prolonged by 6 to 7 additional days (P<0.01). The survival of skin allografts from either beta7-/- or beta7+/+ C57BL/6 mice received by SJL/J recipients was not prolonged (P >0.05).Beta7 integrins contribute to skin graft rejection, in accord with their role in mediating the epidermotropism of T-cells during skin inflammation.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Beta7 integrins contribute to skin graft rejection...

on Transplantation Journal Oct 27, 2002

Beta7 integrins contribute to demyelinating diseas...

on Journal of Neuroimmunology Mar 01, 2000

Beta7 integrins contribute to demyelinating diseas...

on Journal of Neuroimmunology Mar 01, 2000

Monoclonal antibody against beta7 integrins, but n...

on Transplantation Journal Nov 15, 2002
More articles like this..