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Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study

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Publisher
BioMed Central
Publication Date
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PMC
Keywords
  • Research Article
Disciplines
  • Medicine

Abstract

1471-2334-4-50.fm ral ss BioMed CentBMC Infectious Diseases Open AcceResearch article Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study Johan Van Weyenbergh*1,3, Gisélia Santana1, Argemiro D'Oliveira Jr4, Anibal F Santos Jr5, Carlos H Costa6, Edgar M Carvalho3,4, Aldina Barral2,3 and Manoel Barral-Netto1,3 Address: 1LIMI, Gonçalo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001 Salvador-BA, Brazil, 2LIP, Gonçalo Moniz Research Center -Oswaldo Cruz Foundation (FIOCRUZ), Rua Waldemar Falcao 121, 40295-001 Salvador-BA, Brazil, 3Institute for Immunological Investigation (iii, Instituto do Milênio), Sao Paulo-SP, Brazil, 4Serviço de Imunologia, HUPES, Salvador-BA, Brazil, 5Instituto de Quimica, UFBA, Salvador-BA, Brazil and 6Infectious Disease Hospital, UFPI, Teresina-PI, Brazil Email: Johan Van Weyenbergh* - [email protected]; Gisélia Santana - [email protected]; Argemiro D'Oliveira - [email protected]; Anibal F Santos - [email protected]; Carlos H Costa - [email protected]; Edgar M Carvalho - [email protected]; Aldina Barral - [email protected]; Manoel Barral-Netto - [email protected] * Corresponding author Abstract Background: The process of elimination of intracellular pathogens, such as Leishmania, requires a Th1 type immune response, whereas a dominant Th2 response leads to exacerbated disease. Experimental human zinc deficiency decreases Th1 but not Th2 immune response. We investigated if zinc and copper levels differ in different clinical forms of leishmaniasis, and if these trace metals might be involved in the immune response towards the parasite. Methods: Blood was collected from 31 patients with either localized cutaneous (LCL), mucosal (ML) or visceral (VL) leishmaniasis, as well as from 25 controls from endemic and non-endemic areas. Anti- Leishmania humoral and cellular immune response were evaluated by quantifying specific plasma IgG, lymphoproli

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