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Brain prostaglandins mediate the bombesin-induced increase in plasma levels of catecholamines

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
59
Issue
15
Identifiers
DOI: 10.1016/0024-3205(96)00445-6
Keywords
  • Bombesin
  • Indomethacin
  • Diclofenac
  • Plasma Adrenaline
  • Plasma Noradrenaline
  • Prostaglandin
  • Thyrotropin Releasing Hormone

Abstract

Abstract Intracerebroventricular (i.c.v.) administration of bombesin (0.1, 1.0, 10.0 nmol/animal) in urethane-anesthetized rats induced long-lasting and dose dependent increases in plasma levels of adrenaline and noradrenaline. These effects of bombesin were inhibited by i.c.v. pretreatment with indomethacin (50–500 μg/animal), while the same dose of indomethacin by the intravenous route was without effect. The bombesin-induced increases in plasma levels of catecholamines were also inhibited by i.c.v. pretreatment with diclofenac (100–500 μg/animal), a cyclooxygenase inhibitor other than indomethacin. I.c.v. administration of thyrotropin releasing hormone (TRH) (10 nmol/animal) also induced increases in plasma levels of adrenaline and noradrenaline, however, these increases were not modified by i.c.v. pretreatment with indomethacin. The present results suggest that the bombesin-induced increases in plasma levels of catecholamines are probably due to prostaglandins synthetized in the brain with this neuropeptide. Furthermore, it is likely that prostaglandins are not always involved in central activation of sympatho-adrenomedullary system by other brain neuropeptides.

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