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Covalent binding of polycyclic aromatic hydrocarbons to adenine correlates with tumorigenesis in mouse skin

Authors
Journal
Cancer Letters
0304-3835
Publisher
Elsevier
Publication Date
Volume
7
Issue
1
Identifiers
DOI: 10.1016/s0304-3835(79)80074-9

Abstract

Summary Mouse epidermal homogenates were utilized to convert various polycyclic aromatic hydrocarbons to metabolites capable of binding covalently with nucleic acids. Poly(G) showed the highest capacity to bind covalently with the hydrocarbons; however, there was no correlation between binding to poly(G) and mouse skin tumorigenicity. On the other hand, covalent binding to poly(A) correlated well with values obtained for binding to DNA and mouse skin tumorigenicity. The order of binding to poly(A) was; 7,12-dimethylbenz[ a]anthracene > benzo[ a]pyrene > dibenz[ a,h]anthracene > dibenz-[ a,c]anthracene.

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