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Osthole attenuates the development of carrageenan-induced lung inflammation in rats

Authors
Journal
International Immunopharmacology
1567-5769
Publisher
Elsevier
Volume
20
Issue
1
Identifiers
DOI: 10.1016/j.intimp.2014.02.013
Keywords
  • Osthole
  • Carrageenan
  • Pleurisy
  • Inflammation
  • Lung
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Osthole has been reported to possess a variety of pharmacological activities, such as antiinflammatory effect. In the present study, we have investigated the effect of osthole on lung inflammation associated with carrageenan-induced pleurisy in rats. The result showed that osthole could inhibit significantly pleural exudates formation and PMNs infiltration. Histological examination revealed osthole could reduce lung inflammation in rats treated with carrageenan. The myeloperoxidase (MPO) level was examined in pleural exudates. The result showed that osthole could attenuate MPO level in pleural exudates. Further studies showed osthole could decrease tumor necrosis factor alpha (TNF-α) and interleukin 1beta (IL-1β) levels in the lungs. Taken together, the present results suggested that osthole could inhibit lung inflammation on carrageenan-induced pleurisy in rats and that could be related to a reduction of PMNs infiltration and release of inflammatory factors.

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