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Interfacial reactions and thrombosis

Bioelectrochemistry and Bioenergetics
Publication Date
DOI: 10.1016/0302-4598(77)80137-2
  • Biology
  • Chemistry
  • Medicine
  • Pharmacology


Abstract The in vivo interactions of biomaterials and pharmacologic agents with the components of the cardiovascular system in experimental animals and humans have been investigated using several physicochemical techniques. The results suggest that decreased negativity of vascular interface makes the vascular system more susceptible to thrombosis. The in-vivo patency of an implantable cardiovascular prosthesis is determined by the rest potential of the alloy in saline. Surface contamination during manufacture, storage, cleaning and sterilization prior to and during actual implantation leads to thrombogenesis. Highly thrombogenic materials — copper and titanium-aluminum alloy (Ti-6Al-4V) remain patent in-vivo if maintained at a highly negative potential by ( a) cathodic polarization, or ( b) by galvanic coupling. The implantation behavior of practical prostheses has been found to be significantly improved by ( a) electrochemical cleaning/polishing and ( b) taking special precautions to preclude attachment of particulate matter to the prosthesis during sterilization (by whatever method this is achieved), and implantation. Particulate matter on the prostheses can be identified by scanning electron microscopic examination of the surface coupled with X-ray energy dispersion spectroscopy. We were able to identify the surface contamination and locate the source using these techniques in stored prostheses which are ordinarily implanted. Similarly the effects of drugs on the cardiovascular system have been assessed in experimental animals using electrokinetic and electron-optical techniques. Electroosmotic flow studies across arteries and veins of experimental animals administered on various drugs yields information on the alteration of the vascular surface charge due to ingestion of

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