Apple, Cherry, and Blackcurrant Increases Nuclear Factor Kappa B Activation in Liver of Transgenic Mice

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Apple, Cherry, and Blackcurrant Increases Nuclear Factor Kappa B Activation in Liver of Transgenic Mice

Authors
Publisher
Routledge
Keywords
  • However
  • Blackcurrant
  • Nuclear Factor Kappa B (Nf-B) Is Essential In Normal Physiology
  • And Several Human Disorders Involve Inappropriate Regulation Of Nf-B
  • Diets Dominated By Plant-Based Foods Protect Against Chronic Diseases
  • And Several Food Derived Compounds Have Been Identified As Promising Nf-B Modulators
  • We Investigated The Effects Of Diets Supplemented With Apple
  • Or Cherries On Lipopolysaccharide (Lps)-Induced Nf-B Activation In Transgenic Nf-B-Luciferase Mice
  • Whole Body And Organ Specific Nf-B Activities Were Determined
  • The Mice Had Ad Libitum Access To The Respective Experimental Diets For 7 Days
  • On Day 7
  • All Mice Were Given An Lps-Injection (2
  • 5 Mg/Kg)
  • And Nf-B Activation Was Monitored By In Vivo Imaging For 6 H
  • After Imaging
  • Blood Samples Were Taken
  • The Mice Were Euthanized
  • And Ex Vivo Imaging Of Organs Was Performed
  • Compared To The Control Group
  • The Apple And Cherry Groups Had Slightly Higher Whole-Body Nf-B Activation At 4 H
  • And All 3 Experimental Groups Had Higher Nf-B Activation At 6 H
  • Lps-Induced Nf-B Activation In Liver Was Increased With All 3 Experimental Diets
  • But No Effects Were Observed In Other Organs
  • Our Findings Indicate That High Intakes Of Lyophilized Fruits Modulate In Vivo Nf-B Signaling In The
  • Consequences Of This Nf-B Modulation In Hepatic Tissue Needs Further Investigation

Abstract

Apple, Cherry, and Blackcurrant Increases Nuclear Factor Kappa B Activation in Liver of Transgenic Mice - DTU Orbit (31/03/14) Apple, Cherry, and Blackcurrant Increases Nuclear Factor Kappa B Activation in Liver of Transgenic Mice - DTU Orbit (31/03/14) Balstad, Trude; Paur, Ingvild; Poulsen, Morten; Markowski, Jaroslaw; Kolodziejczyk, Krzysztof; Dragsted, Lars; Myhrstad, Mari C. W.; Blomhoff, Rune / Apple, Cherry, and Blackcurrant Increases Nuclear Factor Kappa B Activation in Liver of Transgenic Mice. In: Nutrition and Cancer, Vol. 62, No. 6, 2010, p. 841-848. Publication: Research - peer-review › Journal article – Annual report year: 2010

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