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Rapid and reversible changes in myosin heavy chain expression in response to increased neuromuscular activity of rat fast-twitch muscle

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
268
Issue
1
Identifiers
DOI: 10.1016/0014-5793(90)80976-p
Keywords
  • Chronic Low-Frequency Stimulation
  • Myosin Heavy Chain Mrna Isoform
  • Fast-Twitch Muscle

Abstract

Abstract Chronic 10 Hz stimulation of rat fast-twitch muscle induced rapid and reversible changes in the tissue levels offast myosin heavy chain (HC) mRNA isoforms. These changes consisted of a rapid decrease in HCIIb mRNA and a progressive increase in HCIIa mRNA. After 15 days, the HCIIb mRNA normally amounting to approximately 80%, had decreased to less than 5% of the sum of the two HC mRNA isoforms. HCIIb mRNA was again detectable one day after cessation of stimulation and progressively increased at the expense of HCIIa mRNA with ongoing recovery. These results point to a down-regulation of the HCIIb gene by the applied stimulus pattern which, conversely, enhances the expression of the HCIIa gene.

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