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Rational Prescribing in Primary Care (RaPP): A Cluster Randomized Trial of a Tailored Intervention

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plme-03-06-21 783..791 Rational Prescribing in Primary Care (RaPP): A Cluster Randomized Trial of a Tailored Intervention Atle Fretheim 1* , Andrew D. Oxman 1 , Kari Ha˚velsrud 1 , Shaun Treweek 2 , Doris T. Kristoffersen 1 , Arild Bjøørndal 1 1 Norwegian Knowledge Centre for Health Services, Oslo, Norway, 2 Tayside Centre for General Practice, University of Dundee, Dundee, United Kingdom Funding: The study was funded by the Norwegian Ministry of Health, the Norwegian Directorate for Health and Social Affairs, and the Norwegian Knowledge Centre for Health Services. The funding agencies had no influence on the design or conduct of the study. Competing Interests: All the authors are, or have been, employed by the Norwegian government, which has a substantial interest in improving professional practice in Norway and in containing the costs of health care. The clinical practice guidelines and the study design have not been endorsed by the government or any other organization and represent the views of the authors. No other competing interests are declared. Academic Editor: Steve Jan, George Institute for International Health, United States of America Citation: Fretheim A, Oxman AD, Ha˚velsrud K, Treweek S, Kristoffersen DT, et al. (2006) Rational Prescribing in Primary Care (RaPP): A cluster randomized trial of a tailored intervention. PLoS Med 3(6): e134. DOI: 10.1371/journal.pmed.0030134 Received: August 18, 2005 Accepted: March 2, 2006 Published: June 6, 2006 DOI: 10.1371/journal.pmed.0030134 Copyright: � 2006 Fretheim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abbreviations: CI, confidence interval; GEE, generalized estimating equations; LDL, low-density lipoprotein * To whom correspondence should be addressed. E-mail: atle.fretheim@ A B S T R A C T Backgro

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