Affordable Access

Lateral geniculate lesions block circadian phase-shift responses to a benzodiazepine.

Authors
Publication Date
Source
PMC
Keywords
  • Research Article
Disciplines
  • Biology
  • Pharmacology

Abstract

Several pharmacological treatments, including application of an excitatory neurotoxin to the lateral geniculate nucleus (LGN) and systemic administration of triazolam, a clinically effective benzodiazepine, can elicit large phase shifts in a circadian rhythm according to the time of administration. The hypothesis that the LGN might mediate the effect of triazolam on circadian clock function was tested. Bilateral lesions of the LGN, which destroyed the connection from the intergeniculate leaflet to the suprachiasmatic nucleus, blocked phase-shift responses to triazolam. The requirement of an intact LGN for triazolam to shift circadian phase suggests that the LGN may be a site through which stimuli gain access to the circadian clock to modulate rhythm phase and entrainment.

There are no comments yet on this publication. Be the first to share your thoughts.