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Non-standard amino acids in peptide design and protein engineering

Elsevier Science Ltd.
Publication Date
  • Molecular Biophysics Unit
  • Biology
  • Chemistry
  • Design
  • Engineering


The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Templates for secondary-structure nucleation and recent experiences in the incorporation of novel residues into proteins are considered.

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