Affordable Access

Non-standard amino acids in peptide design and protein engineering

Authors
Publisher
Elsevier Science Ltd.
Publication Date
Keywords
  • Molecular Biophysics Unit
Disciplines
  • Biology
  • Chemistry
  • Design
  • Engineering

Abstract

The introduction of non-coded amino acids with well defined stereochemical and functional properties will greatly enhance the scope of protein design and engineering. The present state of methodologies for incorporation of non-coded residues into proteins is examined. The prospects for conformationally constrained amino acid residues are evaluated in the light of peptide structural studies. Templates for secondary-structure nucleation and recent experiences in the incorporation of novel residues into proteins are considered.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments