Abstract The aim of this study is to determine whether a link exists between clinical wound problems and positive bacterial culture of the femoral head after primary hip arthroplasty. Clinical data were retrieved for 24 culture-positive and 26 culture-negative patients. Coagulase-negative Staphylococcus was the commonest pathogen, cultured in 19 of the 24 culture-positive femoral heads donated to a regional bone bank. Wound problems occurred in 2 of the patients from the culture-positive group and 4 of the patients from the culture-negative group. The relative risk of wound problems was 0.54 in the culture-positive group. Based on the available evidence in this preliminary short-term retrospective review, positive microbiology from donated femoral heads has no clinical implication in the donors. The practice of reporting culture-positive femoral heads should be continued.