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Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
195
Issue
2
Identifiers
DOI: 10.1016/0304-3940(95)11783-s
Keywords
  • Antiepileptic Drugs
  • Genetically Epilepsy-Prone Rats
  • Sound-Induced Seizures
  • Tonic/Clonic Seizures
  • Absence Seizures

Abstract

Abstract D-20443 is an experimental antiepileptic drug. Its mechanism of antiepileptic action is unknown. We evaluated the anticonvulsant effectiveness of D-20443 against sound-induced seizures in genetically epilepsy-prone rats (GEPRs). This compound produced anticonvulsant effects against sound-induced seizures in moderate seizure (GEPRs (GEPR-3s) at significantly lower doses than in severe seizure GEPRs (GEPR-9s). Based on these data and on the responses of GEPRs to other antiepileptic drugs, we predict that D-20443 will be a broad spectrum antiepileptic agent in humans. That is, we predict that D-20443 will suppress both tonic/clonic and absence seizures in humans.

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