Abstract Ten oral contraceptive (OC) users and six controls were fed two experimental diets containing 39% of the calories as sucrose or wheat starch for 6 weeks. The two groups of OC users (six using 50 μg and four using 80 to 100 μg mestranol) did not have significantly different response levels of serum insulin, glucose, uric acid, or blood lactate. Insulin levels of the OC users after the sucrose load were significantly higher at 1 hour on the sucrose than on the starch diet or the response of the controls on either diet. Fasting uric acid was significantly higher in the OC users with a significant decrease by 3 hours. Insulin response and fasting uric acid of all groups after the sucrose diet was significantly higher than after the starch.