Affordable Access

Publisher Website

Rab proteins

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
0167-4889
Publisher
Elsevier
Publication Date
Volume
1404
Identifiers
DOI: 10.1016/s0167-4889(98)00050-0
Keywords
  • Rab Gtpase
  • Intracellular Transport
  • Golgi Apparatus
Disciplines
  • Biology

Abstract

Abstract Rab proteins form the largest branch of the Ras superfamily of GTPases. They are localized to the cytoplasmic face of organelles and vesicles involved in the biosynthetic/secretory and endocytic pathways in eukaryotic cells. It is now well established that Rab proteins play an essential role in the processes that underlie the targeting and fusion of transport vesicles with their appropriate acceptor membranes. However, the recent discovery of several putative Rab effectors, which are not related to each other and which fulfil diverse functions, suggests a more complex role for Rab proteins. At least two Rab proteins act at the level of the Golgi apparatus. Rab1 and its yeast counterpart Ypt1 control transport events through early Golgi compartments. Work from our laboratory points out a role for Rab6 in intra-Golgi transport, likely in a retrograde direction.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Rab proteins.

on Biochimica et Biophysica Acta Aug 14, 1998

Zebrafish Rab5 proteins and a role for Rab5ab in n...

on Developmental Biology Jan 15, 2015

Phylogeny and evolution of Rab7 and Rab9 proteins

on BMC Evolutionary Biology Jan 01, 2009
More articles like this..