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Studies of chromogranin A

Authors
Publisher
McGill University
Publication Date
Keywords
  • Biology
  • Molecular.
Disciplines
  • Biology
  • Medicine

Abstract

Although elaborate in vitro studies have been conducted on CgA, its precise neuroendocrine function and the complete elements that control its neuroendocrine specific expression remain unclear. This project applied transgenic technology to study CgA regulation and function in vivo. For the study of the regulation of CgA gene expression, four constructs, containing one of two promoter portions of the CgA gene (the 184bp proximal promoter portion and the 6kb 5'-flanking region) in two reporter systems (beta-galactosidase and green fluorescent protein systems), were constructed. (Abstract shortened by UMI.)

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