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Thixotropic property in pharmaceutical formulations

Authors
Journal
Journal of Controlled Release
0168-3659
Publisher
Elsevier
Publication Date
Volume
136
Issue
2
Identifiers
DOI: 10.1016/j.jconrel.2009.02.013
Keywords
  • Viscosity
  • Thixotropic Property
  • The Influencing Factors
  • Pharmaceutical Applications
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract This review focuses on the characterization of the thixotropic property, the factors affecting the thixotropic property and its pharmaceutical applications. These factors include pH, temperature, polymer concentrations, polymer modification, polymer combinations, and addition of cations or excipients. The relationships between the rheological properties of thixotropic formulations, and their effects on the controlled drug delivery through various routes including oral, topical, ophthalmic, dental and mucosal administration and pharmacological efficacies were also discussed. The comprehensive analysis of rheological and mechanical properties will provide an insight into the potential usage of thixotropic formulations as drug delivery systems.

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