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Prostaglandins and congeners XXIII(1). Synthesis of 15-deoxy-16-hydroxy-16-methylprostaglandins. The importance of the C13-C14transdouble bond for bronchodilator activity

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
17
Issue
5
Identifiers
DOI: 10.1016/s0090-6980(79)80042-8

Abstract

Abstract The synthesis and bronchodilator activity in the guinea pig of several 15-deoxy-16-hydroxy-16-methylprostaglandin analogs is described. The E 2 (VIa) and E 1 (VIb) analogs are potent bronchodilators comparable in activity to the natural prostaglandins, but possessing a longer duration of effect. Replacement of the C 13-C 14 trans double bond by a cis double bond or an ethylene linkage causes a substantial diminishment of this activity.

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