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A Biosynthetic Enzyme Worms Its Way out of a Conserved Mechanism

Authors
Journal
Structure
0969-2126
Publisher
Elsevier
Publication Date
Volume
21
Issue
10
Identifiers
DOI: 10.1016/j.str.2013.09.002
Disciplines
  • Biology

Abstract

Like many promising drug targets, phosphoethanolamine methyltransferase is part of a pathway that is present in a pathogen but not in mammalian hosts. In this issue of Structure, Lee and Jez describe a structure of this phospholipid biosynthesis enzyme from a parasitic nematode and reveal a reconfigured active site.

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