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Synthesis of ABO histo-blood group type I and II antigens

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Publication Date
Volume
345
Issue
16
Identifiers
DOI: 10.1016/j.carres.2010.08.012
Keywords
  • Abo Histo-Blood Group
  • Abo Type I
  • Abo Type Ii
  • Chemical Synthesis
  • Trichloroacetimidate
  • 7-Octen-1-Yl
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract The ABO histo-blood group system is one of the most clinically important antigen families. As part of our overall goal to prepare the entire set of the A, B and H type I–VI antigens for a range of biochemical investigations, we report herein the synthesis of the type I and II antigens with a 7-octen-1-yl aglycone. This linker was chosen to facilitate not only the future conjugation of the antigens to a protein or solid support but also the synthesis of the H type I and II octyl glycosides for enzyme kinetic studies.

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