Affordable Access

Publisher Website

Comparative mutagenicity of aliphatic epoxides in Salmonella

Authors
Journal
Mutation Research/Genetic Toxicology
0165-1218
Publisher
Elsevier
Publication Date
Volume
172
Issue
2
Identifiers
DOI: 10.1016/0165-1218(86)90069-8
Disciplines
  • Chemistry

Abstract

Abstract 37 aliphatic epoxides comprising 6 subclasses (unsubstituted aliphatic epoxides, halogenated aliphatic epoxides, glycidyl esters, glycidates, glycidyl ethers and diglycidyl ethers) were tested, under code, for mutagenicity in Salmonella strains TA98, TA100, TA1535 and TA1537 and/or TA97 with and without metabolic activation using a standardized protocol. The 4 halogenated aliphatic epoxides and the 4 diglycidyl ethers were all mutagenic. The 2 glycidates were negative in all strain/activation systems used while all 5 glycidyl esters were mutagenic. 3 of the 8 unsubstituted aliphatic epoxides and 11 of the 12 glycidyl ethers were mutagenic. Glycidol also was mutagenic whereas 9,10-epoxyoctadecanoic acid, 2-ethylhexyl ester was not mutagenic. Of the 28 mutagenic compounds, all but neodecanoic acid, 2,3-epoxypropyl ester and 2-ethylhexyl glycidyl ether were detected in TA100 without activation. The latter two were detected only with activation in TA100 and TA1535. The majority of the other 26 chemicals were also mutagenic in TA1535 without activation. Good intra- and interlaboratory reproducibility was seen in the results of each of the 4 chemicals tested in more than one set of experiments. The current results confirm and extend the observations of other investigators regarding structural effects on the mutagenicity of members of the aliphatic epoxide class of chemicals.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Comparative mutagenicity of aliphatic epoxides in...

on Mutation Research/Fundamental... November 1986

Mutagenicity of aliphatic epoxides

on Mutation Research/Genetic Toxi... Jan 01, 1978

Mutagenicity of aliphatic epoxides.

on Mutation Research/Fundamental... November 1978
More articles like this..