Affordable Access

Distinct functional domains of the Salmonella enterica WbaP transferase that is involved in the initiation reaction for synthesis of the O antigen subunit

Publication Date
  • Wbap Is A Membrane Enzyme That Initiates O Antigen Synthesis In Salmonella Enterica By Catalysing Th
  • Wbap Possesses At Least Three Predicted Structural Domains: An N-Terminal Region Containing Four Tra
  • A Large Central Periplasmic Loop
  • And A C-Terminal Domain Containing The Last Transmembrane Helix And A Large Cytoplasmic Tail
  • In This Work
  • We Investigated The Contribution Of Each Region To Wbap Function By Constructing A Series Of Mutant
  • Enterica Serovars Typhi And Typhimurium
  • Truncated Forms Of Wbap Lacking The Periplasmic Loop Exhibited Altered Chain-Length Distributions In
  • Suggesting That This Central Domain Is Involved In Modulating The Chain-Length Distribution Of The O
  • The N-Terminal And Periplasmic Domains Were Dispensable For Complementation Of O Antigen Synthesis I
  • Suggesting That The C-Terminal Domain Carries The Sugar-Phosphate Transferase Activity
  • However
  • Despite The Fact That They Complemented The Synthesis Of O Antigen In The Deltawbap Mutant In Vivo
  • Membrane Extracts Containing Wbap Derivatives Without The N-Terminal Domain Failed To Transfer Radio
  • These Results Suggest That The N-Terminal Region Of Wbap
  • Which Contains Four Transmembrane Domains
  • Is Essential For The Insertion Or Stability Of The Protein In The Bacterial Membrane
  • We Propose That The Domain Structure Of Wbap Enables This Protein Not Only To Function In The Transf
  • Enterica
  • Ecology
  • Medicine


Where Futures Are Built | Postgraduate Prospectus for Entry 2014 | Queen's University Belfast Where Futures Are Built POSTgraduaTe PrOSPecTuS For Entry 2014 rEGIStEr noW For MY QUEEN’S - Hear from our students - Get a homepage tailored to your subject interests - receive the latest Queen’s news and information about upcoming events The fastest way to get the inside track on life at Queen’s university For video clips of Queen’s and to hear what our students have to say, go to CDS 99971 Admissions and Access Service Student Plus Queen’s University Belfast Belfast Bt7 1nn northern Ireland, UK t +44 (0)28 9097 5081 e [email protected] Q ueen’s U niversity B elfast Postg rad uate Prosp ectus 2014 w w w .q ub Q 75 Q B ELF CLAREMONT STREET SAN S SO U CI PARK To City Centre Belfast City Hospital (BCH) The Lanyon Building Union Theological College Riddel Hall PEC Elms VillageQueen’s Sport Upper Malone Ulster Museum Botanic Gardens KEY University Buildings Landmark Buildings The Lanyon Building Roads Footpath Café / Restaurant University Accommodation Crèches 1 2 5 3 4 8 13 14 15 17 6 7 19 20 21 22 25 27 24 26 23 11 10 12 30 31 33 34 35 28 29 32 37 36 EQ H G X1 C F A R N X3 T J X2 V D M BD S P W L 38K Queen’s University Belfast Campus Map School Offices Biological Sciences A Chemistry and Chemical Engineering B Creative Arts P Education C Electronics, Electrical Engineering and Computer Science D English E Geography, Archaeology and Palaeoecology F History and Anthropology G Law J Mathematics and Physics L Mechanical and Aerospace Engineering M Medicine, Dentistry and Biomedical Sciences N Modern Languages H Nursing and Midwifery Q Pharmacy R Planning, Architecture and Civil Engineering S Politics, International Studies

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times