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Antinociceptive and free radical scavenging activities ofCocos nuciferaL. (Palmae) husk fiber aqueous extract

Authors
Journal
Journal of Ethnopharmacology
0378-8741
Publisher
Elsevier
Publication Date
Volume
92
Identifiers
DOI: 10.1016/j.jep.2004.03.013
Keywords
  • Antinociceptive And Free Radical Scavenging Activities
  • Aqueous Extract
  • Cocos Nuciferal. (Palmae)

Abstract

Abstract In the current study, the analgesic and free radical scavenging properties of an aqueous extract from the husk fiber of Cocos nucifera L. (Palmae) were demonstrated by the use of in vivo and in vitro models. The orally administered Cocos nucifera aqueous extract (200 or 400 mg/kg) inhibited the acetic acid-induced writhing response in mice. Tail flick and hot plate assays demonstrated that treatment of animals with this plant extract at 200 mg/kg induced attenuation in the response to a heat stimulus. A LD 50 of 2.30 g/kg was obtained in acute toxicity tests. Topic treatment of rabbits with the Cocos nucifera extract indicated that it does not induce any significant dermic or ocular irritation. In vitro experiments using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) photometric assay demonstrated that this plant extract also possesses free radical scavenging properties.

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