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Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases

Authors
Journal
Journal of Translational Medicine
1479-5876
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
9
Identifiers
DOI: 10.1186/1479-5876-9-s2-i14
Keywords
  • Invited Lecture Presentation
Disciplines
  • Medicine

Abstract

Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases INVITED LECTURE PRESENTATION Open Access Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases Jan Wehkamp From 6th European Workshop on Immune-Mediated Inflammatory Diseases Nice, France. 23-25 November 2011 Inflammatory bowel diseases are characterized by chronic intestinal inflammation at different sites. Data from animal models as well as human patients including gene-associa- tion studies suggest that different components of the innate barrier function are primarily defective. These recent advances support the evolving hypothesis that intestinal bacteria induce inflammation predominantly as a result of a weakened innate mucosal barrier in genetically predisposed individuals. The mechanisms include different defects in epithelial stem cell differentiation, defective pattern recog- nition, autophagy, endosomal stress and others. Secretory cells like the Paneth cell of the small intestinal crypt as well as mucin producing goblet cells seem to be of major impor- tance in the initial stages of the disease process. This talk will discus our current understanding of the primary events of disease and also outline consequences for future thera- peutic consequences. In summary, there is a need for thera- peutic avenues aimed at restoring antimicrobial barrier function to prevent a bacterial-triggered inflammatory response. Published: 23 November 2011 doi:10.1186/1479-5876-9-S2-I14 Cite this article as: Wehkamp: Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases. Journal of Translational Medicine 2011 9(Suppl 2):I14. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar •

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