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On the mechanism of soft tissue calcification induced by complexed iron

Authors
Journal
Experimental and Toxicologic Pathology
0940-2993
Publisher
Elsevier
Publication Date
Volume
45
Identifiers
DOI: 10.1016/s0940-2993(11)80429-x
Keywords
  • Ferric Complexes
  • Iron Transfer
  • Calcium Homeostasis Modification
  • Calfication
  • Soft Tissue

Abstract

Summary The interaction of ferric lactate with Ehrlich carcinoma ascites cells induces a modification of Ca 2+-uptake which is in direct relationship with the iron mass bound to the cells. Competitive binding of iron by deferoxamine indicates that only a part of the bound iron penetrates the cell, and that to trigger a Ca 2+-influx this intracellular iron must be over a threshold concentration. The experimental finding that ferric lactate transfers its iron to albumin and to ATP suggests that in the Ca 2+-uptake modification it works through its iron transfer which provokes the inhibition of the cell calcium homeostasis regulatory systems (Ca 2+-channels, intracellular Ca 2+-binding sites and Ca 2+-pump ATPase). The involvement of ATP in the action of ferric lactate seems related to a higher stability of the complex, and to a larger availability of active iron able to perform the inhibitory process.

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