Affordable Access

SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses

Publication Date
  • <P>The Incidence Of Allergy And Asthma In Developed Countries Is On The Increase And This Trend Look
  • Cd4(+) T Helper 2 (Th2) Cells Are Major Drivers Of These Diseases And Their Commitment Is Controlled
  • Which Are In Turn Regulated By The Suppressor Of Cytokine Signaling (Socs) Proteins
  • We Report That Socs2(-/-) Cd4(+) T Cells Show Markedly Enhanced Th2 Differentiation
  • Socs2(-/-) Mice
  • As Well As Rag1(-/-) Mice Transferred With Socs2(-/-) Cd4(+) T Cells
  • Exhibit Elevated Type 2 Responses After Helminth Antigen Challenge
  • Moreover
  • In In Vivo Models Of Atopic Dermatitis And Allergen-Induced Airway Inflammation
  • Socs2(-/-) Mice Show Significantly Elevated Ige
  • Eosinophilia
  • Type 2 Responses
  • And Inflammatory Pathology Relative To Wild-Type Mice
  • Finally
  • After T Cell Activation
  • Markedly Enhanced Stat6 And Stat5 Phosphorylation Is Observed In Socs2(-/-) T Cells
  • Whereas Stat3 Phosphorylation Is Blunted
  • Thus
  • We Provide The First Evidence That Socs2 Playsan Important Role In Regulating Th2 Cell Expansion And
  • </P>
  • Biology
  • Medicine


1 Ludwig Eichinger and Francisco Rivero (eds.), Dictyostelium discoideum Protocols, Methods in Molecular Biology 983, DOI 10.1007/978-1-62703-302-2_1, © Springer Science+Business Media, LLC 2013 Chapter 1 The Amoebozoa Christina Schilde and Pauline Schaap Abstract The model organism Dictyostelium discoideum is a member of the Amoebozoa, one of the six major divisions of eukaryotes. Amoebozoa comprise a wide variety of amoeboid and fl agellate organisms with single cells measuring from 5 μ m to several meters across. They have adopted many different life styles and sexual behaviors and can live in all but the most extreme environments. This chapter provides an overview of Amoebozoan diversity and compares roads towards multicellularity within the Amoebozoa with inven- tions of multicellularity in other protist divisions. The chapter closes with a scenario for the evolution of Dictyostelid multicellularity from an Amoebozoan stress response. Key words Amoebozoa , Protista , Aggregative multicellularity , Encystation , Sporulation , Morphogenesis , Cyclic AMP signaling , Phylogeny The Dictyostelids have fascinated biologists for over 150 years with their ability to assemble up to a million amoebas into a tactile migrating organism, which, after seeking out a site for spore dis- persal, transforms into a well-balanced fruiting structure. The development of a range of molecular genetic and cell biological procedures for the species Dictyostelium discoideum over the past 30 years has established this species as an important model organ- ism for the study of fundamental cell biological and developmental processes ( 1 ) . More recently, the evolution of social behavior and the study of genes associated with human diseases and bacterial infections have been added to the repertoire of research questions that can be addressed in Dictyostelia ( 2 ) . With putative applications of research in mind,

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times