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Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
7
Issue
5
Identifiers
DOI: 10.1371/journal.pone.0032196
Keywords
  • Research Article
  • Biology
  • Biophysics
  • Radiation Biophysics
  • Radiation Effects
  • Radioprotection
  • Neuroscience
  • Cognitive Neuroscience
  • Learning And Memory
  • Radiobiology
  • Toxicology
  • Neurotoxicology
  • Medicine
  • Mental Health
  • Psychology
  • Cognitive Psychology
  • Learning
  • Social And Behavioral Sciences
Disciplines
  • Medicine

Abstract

The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal studies show that ELF-MF exposure may interfere with the activity of brain cells, generate behavioral and cognitive disturbances, and produce deficits in attention, perception and spatial learning. Although, many research efforts have been focused on the interaction between ELF-MF exposure and the central nervous system, the mechanism of interaction is still unknown. In this study, we examined the effects of ELF-MF exposure on learning in mice using two water maze tasks and on some parameters indicative of oxidative stress in the hippocampus and striatum. We found that ELF-MF exposure (1 mT, 50 Hz) induced serious oxidative stress in the hippocampus and striatum and impaired hippocampal-dependent spatial learning and striatum-dependent habit learning. This study provides evidence for the association between the impairment of learning and the oxidative stress in hippocampus and striatum induced by ELF-MF exposure.

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