Allo-limbal transplantation in patients with limbal stem cell deficiency

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Allo-limbal transplantation in patients with limbal stem cell deficiency

  • Aim - To Report The Outcome Of A Series Of Patients With Stem Cell Deficiency Who Underwent Allo-Lim
  • Methods - Six Consecutive Patients Underwent Allo-Limbal Stem Cell Transplantation
  • The Primary Diagnosis Included Alkali Burn (N = 2)
  • Trachoma (N = 1)
  • Chronic Rosacea Blepharitis And Keratoconjunctivitis (N = 1)
  • Aniridia (N = 1)
  • And Stevens-Johnson Syndrome (N = 1)
  • The Limbal Rim Consisted Of Peripheral Cornea And Perilimbal Sclera
  • Fk-506 Was Used Postoperatively For Immunosuppression
  • Results - The Length Of Follow Up Ranged From 3 To 24 Months (Mean Follow Up 11
  • 8 (Sd 9
  • 3) Months)
  • The Outcome Was Considered Satisfactory In Five Of Six Cases
  • The Corneal Surface Was Completely Epithelialised Within 2 Weeks
  • And There Was A Substantial Improvement In Vision And Symptoms
  • One Patient Had Recurrent Epithelial Defects Related To Eyelid Abnormalities
  • No Side Effects Associated With Systemic Immunosuppression Were Noted
  • Conclusion - Allo-Limbal Transplantation
  • With Systemic Immunosuppression With Fk-506 Is Useful In Reconstruction Of The Ocular Surface With I


1 Ludwig Eichinger and Francisco Rivero (eds.), Dictyostelium discoideum Protocols, Methods in Molecular Biology 983, DOI 10.1007/978-1-62703-302-2_1, © Springer Science+Business Media, LLC 2013 Chapter 1 The Amoebozoa Christina Schilde and Pauline Schaap Abstract The model organism Dictyostelium discoideum is a member of the Amoebozoa, one of the six major divisions of eukaryotes. Amoebozoa comprise a wide variety of amoeboid and fl agellate organisms with single cells measuring from 5 μ m to several meters across. They have adopted many different life styles and sexual behaviors and can live in all but the most extreme environments. This chapter provides an overview of Amoebozoan diversity and compares roads towards multicellularity within the Amoebozoa with inven- tions of multicellularity in other protist divisions. The chapter closes with a scenario for the evolution of Dictyostelid multicellularity from an Amoebozoan stress response. Key words Amoebozoa , Protista , Aggregative multicellularity , Encystation , Sporulation , Morphogenesis , Cyclic AMP signaling , Phylogeny The Dictyostelids have fascinated biologists for over 150 years with their ability to assemble up to a million amoebas into a tactile migrating organism, which, after seeking out a site for spore dis- persal, transforms into a well-balanced fruiting structure. The development of a range of molecular genetic and cell biological procedures for the species Dictyostelium discoideum over the past 30 years has established this species as an important model organ- ism for the study of fundamental cell biological and developmental processes ( 1 ) . More recently, the evolution of social behavior and the study of genes associated with human diseases and bacterial infections have been added to the repertoire of research questions that can be addressed in Dictyostelia ( 2 ) . With putative applications of research in mind,

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