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Cholestatic liver injury after glimepiride therapy

Authors
Journal
Journal of Hepatology
0168-8278
Publisher
Elsevier
Publication Date
Volume
42
Issue
6
Identifiers
DOI: 10.1016/j.jhep.2005.02.011
Keywords
  • Case Report
Disciplines
  • Medicine

Abstract

Drug induced hepatotoxicity has been reported infrequently with sulfonylureas. For glimepiride, a second-generation sulfonylurea there is no report of hepatotoxicity in English literature. A patient with non-insulin-dependent diabetes mellitus who developed cholestatic liver injury soon after initiation of glimepiride therapy is presented. Complete work-up disclosed no other cause for hepatotoxicity including negative serological results for viral hepatitis. Liver biopsy was consistent with drug-induced cholestasis. The patient recovered 50 days after stopping glimepiride with no further recurrences.

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