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Decreased expression of β1- and β2-adrenoceptors in human diabetic atrial appendage

BioMed Central
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  • Original Investigation
  • Medicine
  • Pharmacology

Abstract ral ss BioMed CentCardiovascular Diabetology Open AcceOriginal Investigation Decreased expression of β1- and β2-adrenoceptors in human diabetic atrial appendage U Deniz Dinçer*1, Şahika Güner1, Aydin Tay1, Ebru Arioğlu1, Atilay Tas¸delen2, Sait As¸lamaci2 and Keshore R Bidasee3 Address: 1Department of Pharmacology, Faculty of Pharmacy, University of Ankara, Ankara, Turkey, 2Department of Cardiovascular Surgery, Bas¸kent University School of Medicine, Ankara, Turkey and 3Department of Pharmacology, University of Nebraska Medical Center, 98260 Nebraska Medical Center, Omaha NE, USA Email: U Deniz Dinçer* - [email protected]; Şahika Güner - [email protected]; Aydin Tay - [email protected]; Ebru Arioğlu - [email protected]; Atilay Tas¸delen - [email protected]; Sait As¸lamaci - [email protected]; Keshore R Bidasee - [email protected] * Corresponding author Abstract Background: Using the streptozotocin-induced diabetic rat model, we have recently showed that the expression and function of β1-adrenoreceptor were decreased in the diabetic rat heart. However, the effect of diabetes on expression of β-adrenoreceptors in human cardiac tissue remains undefined. Therefore, the focus of the present study was to investigate the effect of diabetes on mRNA encoding β1- and β2-ARs in human atrial tissues. Methods: Right atrial appendages from five diabetic (mean age 65 ± 4.5; 4 female, 1 male) and five nondiabetic patients (mean age 56.2 ± 2.8; 4 male, 1 female) undergoing coronary artery bypass grafting were collected and assayed using reverse transcriptase-polymerase chain reaction (RT- PCR) for their mRNA content. No patient from these two groups suffered from acute myocardial infarction and/or failure. All diabetic patients received insulin for at least two years and had been diagnosed as diabetics for at least five years. Results: When compared with levels in nondiabetics, steady state levels of mRNA enc

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