Publisher Summary This chapter deals with the selection of appropriate equipment and operating systems to implement the containment strategy. Four containment strategies designated as two, three, four, and five for different control devices are discussed. Strategy two in air-flow containment devices do not rely on specific coupling devices but achieve adequate control for low-hazard materials largely as a result of removal of the airborne contaminants in a unidirectional air-stream, provided that the operator follows suitable procedures. Most contained operations (containment strategy three) rely on the ability to transfer materials, components and parts into and out of an isolator or between vessels contained within it without releasing significant quantities of airborne hazardous materials into the environment. Containment Strategy four systems require closed transfer or coupling devices to be used whose connections are made and broken within an isolator. In totally enclosed systems (Containment Strategy five) all operations are carried out by robotics; the operator has no contact at all with the hazardous material but undertakes all required actions by remote control, normally from outside the area or room in which the transfer operation, inside its own isolator, takes place. The main characteristics and applications of the various control devices are also discussed in the chapter.