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Characterization of dopaminergic influence on striatal-nigral neurotensin systems

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
422
Issue
1
Identifiers
DOI: 10.1016/0006-8993(87)90560-9
Keywords
  • Neurotensin
  • Methamphetamine
  • Dopamine
  • Sch 23390
  • Sulpiride

Abstract

Abstract Dopamine depletion by treatment withα-methyl-p-tyrosine had no effect on methamphetamine-mediated increases in striatal neurotensin (NT) concentrations but significantly attenuated nigral increases; the attenuation in the nigral response was reversed by l-DOPA. Blockade of D 2-receptors, with sulpiride, by itself increased striatal NT levels, while having no effect on the nigral NT system or its response to methamphetamine. In contrast, D 1 blockade with SCH 23390 had no effect of its own on NT levels but significantly blocked the methamphetamine-induced actions in both the striatal and nigral NT systems.

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