Affordable Access

Publisher Website

Characterization of a Novel Population of Low-Density Granulocytes Associated with Disease Severity in HIV-1 Infection

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
7
Issue
11
Identifiers
DOI: 10.1371/journal.pone.0048939
Keywords
  • Research Article
  • Biology
  • Biochemistry
  • Enzymes
  • Enzyme Metabolism
  • Immunology
  • Immune Cells
  • T Cells
  • Immune Response
  • Microbiology
  • Virology
  • Immunodeficiency Viruses
  • Medicine
  • Infectious Diseases
  • Viral Diseases
  • Hiv
  • Hiv Epidemiology
Disciplines
  • Biology
  • Medicine

Abstract

The mechanisms resulting in progressive immune dysfunction during the chronic phase of HIV infection are not fully understood. We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low CD4+ T cell counts. Here we show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are phenotypically different. Importantly, our results reveal that increased frequencies of LDGs correlate with disease severity in HIV+ patients.

There are no comments yet on this publication. Be the first to share your thoughts.