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Clues to remind leukemia in patients with arthritis: case presentations

Pediatric Rheumatology
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Acute lymphocytic leukemia (ALL) may initially present with musculoskeletal symptoms such as pain or swelling, even before appearance of blasts in the peripheral blood. Fifteen to 30% of all ALL patients have musculoskeletal complaints at disease onset. Such presentation may lead to misdiagnosis of the patients causing a delay in proper management. Here, we present 5 patients who were referred to Pediatric Rheumatology Department for the evaluation of arthritis and were finally diagnosed as ALL (table 1).

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