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Secondary Philadelphia chromosome in a patient with acute lymphoblastic leukemia

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
152
Issue
2
Identifiers
DOI: 10.1016/j.cancergencyto.2003.11.006
Disciplines
  • Medicine

Abstract

Abstract We report the case of a patient with acute lymphoblastic leukemia who developed a secondary Philadelphia chromosome–positive clone (Ph +). Although the Ph was not detected at diagnosis with conventional cytogenetic analysis and with molecular methods (reverse transcriptase polymerase chain reaction), the Ph was detected with the same techniques at relapse. This anomaly is usually related to the initiation of the disease, but can be a late event related to progression. We discuss these hypotheses and review the literature.

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