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The effects of the DNP:HSA molar ratio on the quantity and the affinity of rat anti-DNP antibodies in the primary response

Authors
Journal
Immunochemistry
0019-2791
Publisher
Elsevier
Publication Date
Volume
9
Issue
12
Identifiers
DOI: 10.1016/0019-2791(72)90295-9

Abstract

Abstract The molar ratio of DNP to HSA in the immunizing antigen was found to be an important determinant of the late (7 week) primary response of rats. The concentration of ϵ-DNP-lysine binding sites in whole resum increases with increasing DNP:HSA molar ratios and with total antigen dose, while the average affinity constant of the binding sites decreases. The results are discussed as evidence of an increase in the affinity of the reaction of antigen and the receptors on antigen binding cells with increasing degree of hapten substitution of the carrier.

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