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Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
23
Issue
1
Identifiers
DOI: 10.1016/0009-2797(78)90038-8

Abstract

Abstract The covalent binding of [6,7- 3H] ethinylestradiol (EE) and [6,7- 3H] estrone (E) to liver DNA of 200 g female rats was measured 8 h after the administration of 80 μg (9.2 mCi) estrogen by gavage. The binding is 1.5 for EE and 1.1 for E, expressed as binding to DNA/dose, in units of μmol hormone/mol DNA phosphate/mmole hormone/kg body wt. It is in the same order of magnitude as for benzene and about 10 000 times below the binding of typical liver carcinogens, such as aflatoxin B 1 or N,N-dimethylnitrosamine.

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