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Neuronal histamine inhibits methamphetamine-induced locomotor hyperactivity in mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
48
Issue
3
Identifiers
DOI: 10.1016/0304-3940(84)90055-7
Keywords
  • Histamine
  • Histidine
  • Tele-Methylhistamine
  • Methamphetamine
  • α-Fluoromethylhistidine
  • Metoprine
  • Locomotor Activity
  • Mouse
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract Whether central histaminergic (HAergic) neurons mediate the regulation of methamphetamine (MAMP)-induced hyperactivity was clarified. l-histidine (HIS; 500 and 1000 mg/kg i.p.) reduced the locomotor hyperactivity induced by MAMP (1 mg/kg i.p.) in mice, and the effect was significant only at 1000 mg/kg. HIS significantly elevated brain histamine (HA) levels, in both doses, whereas tele-methylhistamine (t-MH) levels were elevated only at 1000 mg/kg. Pretreatment with α-fluoromethylhistidine, a histidine decarboxylase inhibitor, suppressed both behavioral and biochemical effects of HIS. Metoprine, a HA-N-methyltransferase inhibitor, increased brain HA levels, decreased t-MH levels and suppressed the MAMP-induced locomotor hyperactivity. It is concluded that central HAergic systems may play an inhibitory role on the MAMP-induced locomotor hyperactivity.

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