Abstract Thermocouples are being utilized in present-generation fusion experiments, both materials and confinement, and will see increased application as these experiments become more complex. Little is known about the response of thermocouples to radiation exposure of any kind. Nothing is known about 14-MeV neutron effects. We have conducted a room-temperature irradiation at RTNS-II to survey seven common thermocouple alloys for fusion-neutron-induced changes in thermoelectric output. Effects are observable in all materials. In some materials the observed effect is modified or removed by annealing. Other materials exhibit effects which are stable to or enhanced by elevated temperature exposure.